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論文業績

股関節外科

欧文論文

  1. The Relationship Between Subluxation Percentage of the Femoroacetabular Joint and Acetabular Width in Asian Women with Developmental Dysplasia of the Hip.
    Okuzu Y, Goto K, Kawata T, So K, Kuroda Y, Matsuda S.
    J Bone Joint Surg Am. 2017 Apr 5;99(7):
  2. Polyethylene and highly cross-linked polyethylene for cemented total hip arthroplasty: A comparison of over ten-year clinical and radiographic results.
    Kawata T, Goto K, So K, Kuroda Y, Matsuda S.
    J Orthop. 2017 Aug 10;14(4):520-524.
  3. Complete Resection of a Massive Synovial Osteochondromatosis of the Hip Using an Anterior Approach: A Report of Two Cases.
    Kataoka M, Goto K, Kuroda Y, Kawai T, Murata O, Sugimoto M, Matsuda S.
    Case Rep Orthop. 2017;2017:9806863.
  4. Long-term results of total hip arthroplasty using Charnley Elite-Plus stem and the effect of stem geometry on radiographic distal femoral cortical hypertrophy.
    Goto K, Furuya Y, Oda K, Minami R, Sano K, Sugimoto M, Matsuda S.
    J Orthop Sci. 2017 Dec 21. [Epub ahead of print]
  5. Sagittal alignment and mobility of the thoracolumbar spine are associated with radiographic progression of secondary hip osteoarthritis.
    Tateuchi H, Akiyama H, Goto K, So K, Kuroda Y, Ichihashi N.
    Osteoarthritis Cartilage. 2017 Dec 18. [Epub ahead of print]
  6. Daily cumulative hip moment is associated with radiographic progression of secondary hip osteoarthritis.
    Tateuchi H, Koyama Y, Akiyama H, Goto K, So K, Kuroda Y, Ichihashi N.
    Osteoarthritis Cartilage. 2017 Aug;25(8):1291-1298.
  7. Mid- and long-term results of femoral component revision using the cement-in-cement technique: Average 10.8-year follow-up study.
    Okuzu Y, Goto K, So K, Kuroda Y, Matsuda S.
    J Orthop Sci. 2016 ;21(6):810-814.　
  8. Extremely early stage osteonecrosis of the femoral head in a patient with hip pain secondary systemic steroid pulse therapy for Vogt-Koyanagi-Harada syndrome: A case report.
    Kuroda Y, So K, Goto K, Matsuda S.
    Int J Surg Case Rep. 2016;25:97-101.
  9. Radiographic and clinical factors associated with one-leg standing and gait in patients with mild-to-moderate secondary hip osteoarthritis.
    Tateuchi H, Koyama Y, Akiyama H, Goto K, So K, Kuroda Y, Ichihashi N.
    Gait Posture. 2016 Jul 18;49:207-212.
  10. Associations of radiographic degeneration and pain with daily cumulative hip loading in patients with secondary hip osteoarthritis.
    Tateuchi H, Koyama Y, Tsukagoshi R, Kuroda Y, So K, Goto K, Akiyama H, Ichihashi N.
    J Orthop Res. 2016 ;34(11):1977-1983.
  11. Clinical and radiographic evaluation of cemented socket fixation concomitant to acetabular bone grafting fixed with absorbable hydroxyapatite-poly-l-lactide composite screws.
    Goto K, Okuzu Y, So K, Kuroda Y, Matsuda S.
    J Orthop Sci. 2016 Jan;21(1):57-62.
  12. Hip external rotator exercise contributes to improving physical functions in the early stage after total hip arthroplasty using an anterolateral approach: a randomized controlled trial.
    Nankaku M, Ikeguchi R, Goto K, So K, Kuroda Y, Matsuda S.
    Disabil Rehabil. 2016 Nov;38(22):2178-83.
  13. Joint-preserving regenerative therapy for patients with early-stage osteonecrosis of the femoral head.
    Kuroda Y, Matsuda S, Akiyama H.
    Inflamm Regen. 2016 Apr 25;36:4.
  14. Minimum 10-Year Wear Analysis of Highly Cross-Linked Polyethylene in Cementless Total Hip Arthroplasty.
    So K, Goto K, Kuroda Y, Matsuda S.
    J Arthroplasty. 2015 Dec;30(12):2224-6.
  15. Report on Three Consecutive Cases using Computer Tomography 3D Preoperative Planning for Conversion of Arthrodesed Hips to Total Hip Replacements.
    Kuroda Y, Akiyama H, Nankaku M, So K, Goto K, Matsuda S.
    HSS J. 2015 Feb;11(1):76-83.
  16. Modified Mostardi approach with ultra-high-molecular-weight polyethylene tape for total hip arthroplasty provides a good rate of union of osteotomized fragments.
    Kuroda Y, Akiyama H, Nankaku M, So K, Matsuda S.
    J Orthop Sci. 2015 Jul;20(4):633-41.
  17. Rehabilitation program after mesenchymal stromal cell transplantation augmented by vascularized bone grafts for idiopathic osteonecrosis of the femoral head: a preliminary study.
    Aoyama T, Fujita Y, Madoba K, Nankaku M, Yamada M, Tomita M, Goto K, Ikeguchi R, Kakinoki R, Matsuda S, Nakamura T, Toguchida J.
    Arch Phys Med Rehabil. 2015 Mar;96(3):532-9.
  18. Two-staged reconstruction for ankylosed hip with severe limb shortening: a case report.
    Goto K, So K, Kuroda Y, Kawanabe K, Matsuda S.
    Hip Int. 2014 Dec 5;24(6):660-3.
  19. An exploratory clinical trial for idiopathic osteonecrosis of femoral head by cultured autologous multipotent mesenchymal stromal cells augmented with vascularized bone grafts.
    Aoyama T, Goto K, Kakinoki R, Ikeguchi R, Ueda M, Kasai Y, Maekawa T, Tada H, Teramukai S, Nakamura T, Toguchida J.
    Tissue Eng Part B Rev. 2014 Aug;20(4):233-42.
  20. Revision total hip replacement with a cemented long femoral component: minimum 9-year follow-up results.
    So K, Kuroda Y, Matsuda S, Akiyama H.
    Arch Orthop Trauma Surg. 2013 Jun;133(6):869-74.
  21. Is the bone-bonding ability of a cementless total hip prosthesis enhanced by alkaline and heat treatments?
    So K, Kaneuji A, Matsumoto T, Matsuda S, Akiyama H.
    Clin Orthop Relat Res. 2013 Dec;471(12):3847-55.
  22. Developing a novel custom cutting guide for curved peri-acetabular osteotomy.
    Otsuki B, Takemoto M, Kawanabe K, Awa Y, Akiyama H, Fujibayashi S, Nakamura T, Matsuda S.
    Int Orthop. 2013 Jun;37(6):1033-8.
  23. Good short-term outcome of primary total hip arthroplasty with cementless bioactive glass ceramic bottom-coated implants: 109 hips followed for 3–9 years.
    So K, Kanatani KT, Kuroda Y, Nakamura T, Matsuda S, Akiyama H.
    Acta Orthop. 2012 Dec;83(6):599-603.
  24. Load dispersion effects of acetabular reinforcement devices used in revision total hip arthroplasty: a simulation study using finite element analysis.
    Kawanabe K, Akiyama H, Goto K, Maeno S, Nakamura T.
    J Arthroplasty. 2011 Oct;26(7):1061-6.
  25. Bone bonding ability and handling properties of a titania-polymethylmethacrylate (PMMA) composite bioactive bone cement modified with a unique PMMA powder.
    Fukuda C, Goto K, Imamura M, Neo M, Nakamura T.
    Acta Biomater. 2011 Oct;7(10):3595-600.
  26. Prediction of ambulation ability following total hip arthroplasty.
    Nankaku M, Tsuboyama T, Kakinoki R, Akiyama H, Nakamura T.
    J Orthop Sci. 2011 Jul;16(4):359-63.
  27. Treatment of experimental osteonecrosis of the hip in adult rabbits with a single local injection of recombinant human FGF-2 microspheres.
    Kuroda Y, Akiyama H, Kawanabe K, Tabata Y, Nakamura T.
    J Bone Miner Metab. 2010 Nov;28(6):608-16.
  28. Bioactive bone cement with a low content of titania particles without postsilanization: effect of filler content on osteoconductivity, mechanical properties, and handling characteristics.
    Fukuda C, Goto K, Imamura M, Nakamura T.
    J Biomed Mater Res B Appl Biomater. 2010 Nov;95(2):407-13.
  29. Bonding ability evaluation of bone cement on the cortical surface of rabbit’s tibia.
    Goto K, Kawanabe K, Kowalski R, Baker D, Nakamura T.
    J Mater Sci Mater Med. 2010 Jan;21(1):139-46.
  30. Clinical results of the wear performance of cross-linked polyethylene in total hip arthroplasty: prospective randomized trial.
    Ise K, Kawanabe K, Tamura J, Akiyama H, Goto K, Nakamura T.
    J Arthroplasty. 2009 Dec;24(8):1216-20.
  31. Long-term results of cemented total hip arthroplasty for dysplasia, with structural autograft fixed with poly-L-lactic acid screws.
    Goto K, Akiyama H, Kawanabe K, So K, Morimoto T, Nakamura T.
    J Arthroplasty. 2009 Dec;24(8):1146-51.
  32. A new cementless total hip arthroplasty with bioactive titanium porous-coating by alkaline and heat treatment: average 4.8-year results.
    Kawanabe K, Ise K, Goto K, Akiyama H, Nakamura T, Kaneuji A, Sugimori T, Matsumoto T.
    J Biomed Mater Res B Appl Biomater. 2009 Jul;90(1):476-81.
  33. Clinical and radiological evaluation of revision hip arthroplasty using the cement-in-cement technique.
    Goto K, Kawanabe K, Akiyama H, Morimoto T, Nakamura T.
    J Bone Joint Surg Br. 2008 Aug;90(8):1013-8.

和文論文

  1. 南角 学, 濱田 涼太, 細江 拓也, 島村 奈那, 後藤 公志, 黒田 隆, 松田 秀一、変形性股関節症患者の股関節外転トルクは中臀筋と梨状筋の筋萎縮と関連する、Hip Joint 43巻2号 Page S351-S353、2017
  2. 細江 拓也, 南角 学, 西川 徹, 島村 奈那, 濱田 涼太, 黒田 隆, 後藤 公志, 松田 秀一、人工股関節全置換術における脚延長が術後の運動機能に及ぼす影響、 Hip Joint43巻2号 Page S332-S334、2017
  3. 岡畠 章憲, 後藤 公志, 宗 和隆, 黒田 隆, 奥津 弥一郎, 川田 交俊, 伊藤 宣, 松田 秀一、リウマチ患者におけるcemented double taper stemを使用した人工股関節全置換術の短期成績、Hip Joint43巻2号 Page1042-1045、2017
  4. 後藤 公志、【誌上ディベート:人工股関節をめぐる議論-対立する治療法】 (Part4)ポリエチレンカップに対する骨頭径　28mm以下の小径骨頭を用い続ける理由(解説/特集)、 Bone Joint Nerve7巻1号 Page65-69、2017
  5. 島村 奈那, 南角 学, 後藤 公志, 黒田 隆, 松田 秀一、変形性股関節症患者の骨盤前傾角は立ち上がり能力に影響する、 Hip Joint 43巻2号 Page S208-S210、2017
  6. 濱田 涼太, 南角 学, 黒田 隆, 後藤 公志, 松田 秀一、大腿骨頭壊死症例におけるステロイド投与が運動機能に与える影響、Hip Joint43巻2号 Page S266-S268、2017
  7. 黒田隆、猪原登志子、向井久美、浅田隆太、秋山治彦、松田秀一、【ステロイド関連大腿骨頭壊死症の予防と新しい治療】特発性大腿骨頭壊死症に対する成長因子を用いた再生医療(解説/特集) 整形・災害外科 60巻11号 Page1393-1399、2017
  8. 黒田隆、【特発性大腿骨頭壊死症をめぐる最近の展開】 成長因子療法(解説/特集)、Loco Cure (2189-4221)2巻2号 Page136-141, 2016
  9. 黒田 隆、猪原 登志子, 向井 久美, 浅田 隆太, 秋山 治彦, 松田 秀一、患者まで届いている再生医療　特発性大腿骨頭壊死症に対するbFGF含有ゼラチンハイドロゲルを用いた低侵襲再生医療(解説)、再生医療 15巻2号 Page160-166、2016
  10. 黒田隆、秋山治彦、新しい医療技術　特発性大腿骨頭壊死に対する再生医療の取り組み(解説)、整形・災害外科 59巻1号 Page95-103、2016
  11. 南角 学, 青山 朋樹, 黒田 隆、【これまでの10年とこれからの10年-理学療法の発展と課題と夢】 先端医療と理学療法(解説/特集)、理学療法ジャーナル 50巻1号 Page77-79、2016
  12. 南角 学, 西川 徹, 黒田 隆、変形性股関節症患者の骨盤アライメントと腸骨筋の筋萎縮は関連する、Hip Joint41巻Suppl. Page152-154、2015
  13. 片岡 正尚, 後藤 公志, 宗 和隆, 村田 巨樹, 杉本 正幸, 松田 秀一、前方アプローチにて全摘出した股関節滑膜骨軟骨腫症の1例、中部日本整形外科災害外科学会雑誌 58巻4号 Page723-724、2015
  14. 西川 徹, 南角 学, 西村 純, 黒田 隆, 後藤 公志、人工股関節全置換術後早期における患者立脚型評価は運動機能の回復が関連する、Hip Joint 41巻Suppl. Page18-20、2015
  15. 戸口田 淳也, 青山 朋樹, 柿木 良介, 後藤 公志, 笠井 泰成、【整形外科領域における再生医療の最前線】 間葉系幹細胞を用いた骨壊死治療法(解説/特集)、関節外科 34巻5号 Page430-435、2015
  16. 後藤 公志, 古屋 佑樹、フランジタイプのElite Plus stemの抜去には注意が必要である、Hip Joint 40巻 Page1029-1031、2014
  17. 後藤 公志、吸収性材料を移植骨固定に用いた臼蓋形成術(Spitzy変法)の術後短期成績、中部日本整形外科災害外科学会雑誌 56巻1号 Page27-28、2013
  18. 樽見 映里, 伊藤 宣, 後藤 公志, 藤田 俊史, 吉富 啓之, 中村 孝志、大腿骨転子部骨折に対し一期的にTHAを行ったRA股の1症例、中部日本整形外科災害外科学会雑誌 54巻5号 Page949-950、2011
  19. 戸口田 淳也, 青山 朋樹, 後藤 公志, 柿木 良介, 笠井 泰成、【幹細胞治療-基礎研究の進歩と臨床応用-】 臨床応用の進歩　大腿骨頭無腐性壊死症に対する細胞治療(解説/特集)、日本臨床69巻12号 Page2225-2230、2011
  20. 後藤 公志, 中村 孝志、新しい医療技術　新しい生体活性骨セメント(解説)、整形・災害外科 54巻12号 Page1503-1507、2011
  21. 中村 孝志, 宗 和隆、【運動器領域の人工臓器の進歩-人工骨と人工股関節-】 アルカリ加熱処理生体活性化チタン合金人工関節の実用化(解説/特集)、人工臓器 40巻1号 Page62-65、2011
  22. 岡畠 章憲, 秋山 治彦, 後藤 公志, 宗 和隆, 中村 孝志、カップ関節形成術後に人工股関節置換術をおこなった症例の検討(原著論文)、日本人工関節学会誌 40巻 Page114-115、2010
  23. 後藤 公志, 秋山 治彦, 宗 和隆, 中村 孝志, 川那辺 圭一、安全にCPO(寛骨臼回転骨切り術)を行うための術前3Dシミュレーション、Hip Joint36巻 Page367-370、2010
  24. 安芸 浩嗣, 南角 学, 西村 純, 藤田 容子, 秋山 治彦, 後藤 公志, 中村 孝志、アプローチ方法の違いが人工股関節全置換術後の機能回復に及ぼす影響　Modified mini-one antero-lateral incision(MMIS)法とDall法の比較、Hip Joint 36巻Suppl. Page134-136、2010
  25. 藤田 容子, 南角 学, 西村 純, 安藝 浩嗣, 秋山 治彦, 後藤 公志, 中村 孝志、年齢が人工股関節全置換術後における術後経過に及ぼす影響　杖歩行自立までの期間と運動機能の回復過程に着目して、Hip Joint 36巻Suppl. Page131-133、2010
  26. 西村 純, 南角 学, 秋山 治彦, 後藤 公志, 中村 孝志、変形性股関節症患者の股関節機能と前額面上における骨盤および脊椎のアライメントの関連性、Hip Joint 36巻Suppl. Page60-62、2010
  27. 川那辺 圭一, 秋山 治彦, 後藤 公志, 中村 孝志、横止め螺子付き大腿骨ステムの使用経験(解説)、東海関節 1巻 Page1-5、2009
  28. 三浦 和美, 八田 太一, 村山 敏典, 秋山 治彦, 後藤 公志, 赤水 尚史, 中村 孝志, 横出 正之、自主臨床試験に参加した被験者を対象としたCRCの貢献に関する質問票調査、臨床薬理 41巻1号 Page53-57、2010

脊椎外科

  1. Clinical and radiological features of spinal extradural arachnoid cysts: Valve-like mechanism involving the nerve root fiber as a possible cause of cyst expansion. Morizane K, Fujibayashi S,Otsuki B, Sakamoto T, Tsutsumi R, Odate S, Kusuba A, Matsuda S. J Orthop Sci. 2018 Feb 13. pii: S0949-2658(18)30021-6. doi: 10.1016/j.jos.2018.01.005. [Epub ahead of print]
  2. Sagittal imbalance treated with L5 pedicle subtraction osteotomy with short lumbar fusion from L4 to sacrum using four screws into L4 for enhanced fixation two additional vertebral screws: a technical note. Wangdi K,Otsuki B, Fujibayashi S, Tanida S, Masamoto K, Matsuda S. Eur Spine J. 2018 Feb 7. doi: 10.1007/s00586-018-5487-2. [Epub ahead of print]
  3. Factors influencing spinal sagittal balance, bone mineral density, and Oswestry Disability Index outcome measures in patients with rheumatoid arthritis. Masamoto K,Otsuki B, Fujibayashi S, Shima K, Ito H, Furu M, Hashimoto M, Tanaka M, Lyman S, Yoshitomi H, Tanida S, Mimori T, Matsuda S.Eur Spine J. 2017 Nov 28.
  4. Occipital and external acoustic meatus to axis angle as a predictor of the oropharyngeal space in healthy volunteers: a novel parameter for craniocervical junction alignment. Morizane K, Takemoto M, Neo M, Fujibayashi S,Otsuki B, Kawata T, Matsuda S.Spine J. 2017 Sep 28. pii: S1529-9430(17)31000-8.
  5. Risk factors for implant removal after spinal surgical site infection. Tsubouchi N, Fujibayashi S,Otsuki B, Izeki M, Kimura H, Ota M, Sakamoto T, Uchikoshi A, Matsuda S. Eur Spine J. 2017 Sep 14.
  6. In vivo experimental study of anterior cervical fusion using bioactive polyetheretherketone in a canine model.Shimizu T, Fujibayashi S, Yamaguchi S,Otsuki B, Okuzu Y, Matsushita T, Kokubo T, Matsuda S.PLoS One. 2017 Sep 8;12(9):
  7. Incidence and Risk Factors of Anterior Arch Fracture of The Atlas Following C1 Laminectomy Without Fusion.Shimizu T,Otsuki B, Fujibayashi S, Kumamoto S, Hijikata Y, Shimizu Y, Takemoto M, Ota M, Ito H, Matsuda S. Spine (Phila Pa 1976). 2017 Sep 6.
  8. Influence of spinopelvic alignment and morphology on deviation in the course of the psoas major muscle.Tanida S, Fujibayashi S,Otsuki B, Masamoto K, Matsuda S.J Orthop Sci. 2017 Nov;22(6):1001-1008.
  9. Efficacy of Target Drug Delivery and Dead Space Reduction Using Antibiotic-loaded Bone Cement for the Treatment of Complex Spinal Infection. Masuda S, Fujibayashi S, Otsuki B, Kimura H, Matsuda S. Clin Spine Surg. 2017 Nov;30(9):E1246-E1250
  10. Preoperative assessment of the ureter with dual-phase contrast enhanced computed tomography for lateral lumbar fusion procedures. Fujibayashi S, Otsuki B, Kimura H, Tanida S, Masamoto K, Matsuda S. , J Orthop Sci. 2017 May; 22(3), 420-24
  11. Clinical and Radiographic Outcomes of C1 Laminectomy Without Fusion in Patients With Cervical Myelopathy That Is Associated With a Retro-odontoid Pseudotumor. Takemoto M, Neo M, Fujibayashi S, Sakamoto T, Ota M, Otsuki B, Kaneko H, Umebayashi T. Clin Spine Surg. 2016 Dec;29(10):E514-E521. PMID: 27879510
  12. Lumbar Spinal Surgery in Patients With Parkinson Disease: A Multicenter Retrospective Study. Kimura H, Fujibayashi S, Otsuki B, Takemoto M, Shikata J, Odate S, Matsushita M, Kusuba A, Kim Y, Sakamoto T, Watanabe K, Ota M, Izeki M, Tsubouchi N, Matsuda S. Clin Spine Surg. 2016 Oct 6. [Epub ahead of print] PMID: 27753699
  13. Vertebral Endplate Cyst as a Predictor of Nonunion after Lumbar Interbody Fusion: Comparison of Titanium and Polyetheretherketone Cages. Tanida S, Fujibayashi S, Otsuki B, Masamoto K, Takahashi Y, Nakayama T, Matsuda S. Spine (Phila Pa 1976). 2016 Apr 6. [Epub ahead of print]
  14. Spontaneous anterior arch fracture of the atlas following C1 laminectomy without fusion: A report of three cases and finite element analysis. Shimizu T, Otsuki B, Fujibayashi S, Takemoto M, Ito H, Sakamoto T, Adachi T, Matsuda S.J Orthop Sci. 2016 Mar 16.
  15. Utility of a custom screw insertion guide and a full-scale, color-coded 3D plaster model for guiding safe surgical exposure and screw insertion during spine revision surgery. Otsuki B, Takemoto M, Fujibayashi S, Kimura H, Masamoto K, Matsuda S. J Neurosurg Spine. 2016 Mar 11:1-9.
  16. Effects of Lumbar Stiffness after Lumbar Fusion Surgery on Activities of Daily Living. Kimura H, Fujibayashi S, Otsuki B, Takahashi Y, Nakayama T, Matsuda S. Spine (Phila Pa 1976). 2015 Nov 30.
  17. A multi-center study of reoperations within 30 days of spine surgery. Shimizu T, Fujibayashi S, Takemoto M, Otsuki B, Kimura H, Ota M, Kusuba A, Kim Y, Soeda T, Watanabe K, Sakamoto T, Uchikoshi A, Tsubouchi N, Matsuda S. Eur Spine J. 2015 Jul 14.
  18. Successful Total En Bloc Spondylectomy of T7 Vertebra for Hepatocellular Carcinoma Metastasis after Living Donor Liver Transplantation. Kimura H, Fujibayashi S, Shimizu T, Otsuki B, Murakami H, Kaido T, Uemoto S, Matsuda S. Spine 2015, Apr 17
  19. Additive-manufactured patient-specific titanium templates for thoracic pedicle screw placement: novel design with reduced contact area. Takemoto M, Fujibayashi S, Ota E, Otsuki B, Kimura H, Sakamoto T, Kawai T, Futami T, Sasaki K, Matsushita T, Nakamura T, Neo M, Matsuda S. Eur Spine J 2015 Mar
  20. Effect of indirect neural decompression through oblique lateral interbody fusion for degenerative lumbar disease. Fujibayashi S, Hynes RA, Otsuki B, Kimura H, Takemoto M, Matsuda S. Spine (Phila Pa 1976). 2015 Feb 1;40(3):E175-82.
  21. Otsuki B, Fujibayashi S, Takemoto M, Kimura H, Shimizu T, Matsuda S.Diffuse idiopathic skeletal hyperostosis (DISH) is a risk factor for further surgery in short-segment lumbar interbody fusion.Eur Spine J. 2014 Oct 1. [Epub ahead of print]
  22. Kimura H, Fujibayashi S, Takemoto M, Otsuki B, Matsuda S.Spontaneous Reduction in Ossification of the Posterior Longitudinal Ligament of the Thoracic Spine After Posterior Spinal Fusion without Decompression: A Case Report. Spine (Phila Pa 1976). 2013 Dec 30.
  23. Izeki M, Neo M, Fujibayashi S, Takemoto M, Otsuki B, Watanabe M, Koizumi K, Matsuda A, Nagai K, Matsuda S.,Utility of the Analysis of Intracranial Venous Sinuses Using Preoperative Computed Tomography Venography for Safe Occipital Screw Insertion. Spine (Phila Pa 1976). 2013 May 21. [Epub ahead of print]
  24. Izeki M, Neo M, Ito H, Nagai K, Ishizaki T, Okamoto T, Fujibayashi S, Takemoto M, Yoshitomi H, Aoyama T, Matsuda S.,Reduction of Atlantoaxial Subluxation Causes Airway Stenosis. Spine (Phila Pa 1976). 2013 Feb 7. [Epub ahead of print]

手の外科

上肢外科関連臨床業績（10年分）

  1. Treatment of advanced Kienbock’s disease by using a lunate plasty combined with capitate shortening. The 5th Congress of the Asia Pacific Federation of Societies for Surgery of the Hand International proceedings Medimond (Italy) 2004, 145-148.
  2. Treatment of progressive necrosis of the lunate bone (Kienbock disease) after unsuccessful radial osteotomy: Scand J Plast Reconstr Surg Hand Surg 2007;18: 1-5.
  3. Skin defects covered using medialis pedis flaps after correction of severe flexion contracture of the big toes due to plantar fibromatosis—a case report. J Ortho Sci 2006;11(1): 103-109.
  4. The Outcome of perioperative humeral condylar fractures in total elbow arthroplasty in RA patients. Journal of Bone and Joint Surgery 2007;89(B): 62-65.
  5. Treatment of avascular necrosis of the capitulum of a humerus by using a free vascularized osteoperiosteal graft from the medial condyle of the femur.. J Shoulder Elbow Surg 2007;18;1-5.
  6. Functioning transferred free muscle innervated by part of the vascularized ulnar nerve connecting the contralateral cervical seventh root to the median nerve: Case report. J Brachial Plexus and Peripheral Nerve Injury. 2: 18, 2007.
  7. Treatment of post-traumatic painful neuromas at the fingertip using neurovascular island flaps. J Hand Surg 2008;33A(3): 348-352.
  8. Factors Affecting the Success of Arterialised Venous Flaps in the Hand. Injury 2008;Supple 4:18-24.
  9. Reconstruction of a phalangeal bone using a vascularized metacarpal bone graft nourished by a dorsal metacarpal artery. Injury 2008;Supple 4: 25-28.
  10. Transverse and longitudinal osteotomy for the treatment of macrodactylia simplex congenita- a case report. Hand Surgery 2008; 13(2): 121-128.
  11. Soft-tissue injury in orthopaedic trauma. Injury 2008; Supple 4: 3-17.
  12. The volar approach to proximal interphalangeal joint arthroplasty. Tech Hand Up Extrem Surg 2009 Mar;13(1):47-53.
  13. Resection arthroplasty of the shoulder. Minerva Orthopedica e traumatologica 2009; 60 (1): 47-52.
  14. Revision carpal tunnel syndrome. Minerva Orthopedica e traumatologica 2009; 60 (1): 119-127.
  15. Comparison between partial ulnar and intercostal nerve transfers for reconstructing elbow flexion in patients with upper brachial plexus injuries. J Brachial Plexus and Peripheral Nerve Injury. 2010; 26: 4-8.
  16. Hand and wrist infections in the intravenous drug abuser. Current Orthopedic Practice. 2010; 21(6): 573-576.
  17. A comparison of workers’ compensation patients and nonworkers’ compensation patients undergoing endoscopic carpal tunnel release. Hand Surg 2010; 15: 75-80.
  18. Treatment of a type 3B hypoplastic thumb using extra phalanges from the contralateral duplicated thumb: case report. J Hand Surg Am 2011;36(9):1492-1496
  19. Simultaneous reconstruction of a palmar skin defect and digital artery with an arterialized venous flap after correction of camptodactyly with severe flexion deformity. Hand 2011:6(4):445-449.
  20. Open wedge flexion osteotomy of the matacarpal neck for the avascular necrosis of the third metacarpal head: Case report. Hand Surg 2012;17(2): 251-253.
  21. Phalangeal fracture. Current Orhtopedic Practice 2012;23(4): 273-283.
  22. Morphology and histology of the collapsed lunate in adavanced Kienbock disease. Hand Surg 2013 in press
  23. A modified tension band wiring technique for treatment of the bony mallet finger. Hand Surg 2013 in press.

末梢神経保存

  1. Storage and allogeneic transplantation of peripheral nerve using a green tea polyphenol solution in a canine model. J Brachial Plex Peripher Nerve Inj. 2010 Nov 28;5:17.
  2. Successful storage of peripheral nerves using University of Wisconsin solution with polyphenol.J Neurosci Methods. 2007 Jan 15;159(1):57-65. Epub 2006 Aug 30.
  3. Optimal conditions for peripheral nerve storage in green tea polyphenol: an experimental study in animals.J Neurosci Methods. 2005 Jun 30;145(1-2):255-66.
  4. Peripheral nerve allografts stored in green tea polyphenol solution.Transplantation. 2005 Mar 27;79(6):688-95.
  5. Successful storage of peripheral nerve before transplantation using green tea polyphenol: an experimental study in rats.Exp Neurol. 2003 Dec;184(2):688-96.

末梢神経再生

  1. Nerve regeneration promoted in a tube with vascularity containing bone marrow-derived cells. Cell Transplant. 2007;16(8):811-22.
  2. Basic fibroblast growth factor promotes nerve regeneration in a C- -ion-implanted silicon chamber.Brain Res. 2006 May 23;1090(1):51-7. Epub 2006 May 4.
  3. Rat nerve regeneration through a silicone chamber implanted with negative carbon ions.Brain Res Dev Brain Res. 2003 Jan 10;140(1):127-31.
  4. Nerve regeneration over a 20-mm gap through a nerve conduit containing blood vessels in rats: the influence of interstump distance on nerve regeneration.J Neurosurg Sci. 1998 Mar;42(1):11-21.
  5. Nerve regeneration over a 25 mm gap in rat sciatic nerves using tubes containing blood vessels: the possibility of clinical application.Int Orthop. 1997;21(5):332-6.
  6. Relationship between axonal regeneration and vascularity in tubulation–an experimental study in rats.Neurosci Res. 1995 Aug;23(1):35-45.

その他

  1. Effects of continuous intravenous infusion of MCI-186 on functional recovery after spinal cord injury in rats.J Neurotrauma. 2011 Feb;28(2):289-98.
  2. Regeneration of osteonecrosis of canine scapho-lunate using bone marrow stromal cells: possible therapeutic approach for Kienböck disease.Cell Transplant. 2006;15(5):411-22.
  3. Detection of the proliferated donor cells in bone grafts in rats, using a PCR for a Y-chromosome-specific gene.J Orthop Sci. 2002;7(2):252-7.

骨格形成・機能制御

参考業績

  1. Yukio Nakamura, Koji Yamamoto, Xinjun He, Bungo Otsuki, Youngwoo Kim, Hiroki Murao, Tsunemitsu Soeda, Noriyuki Tsumaki, Jian Min Deng, Zhaoping Zhang, Richard R. Behringer, Benoit de Crombrugghe, John H. Postlethwait, Matthew L. Warman, Takashi Nakamura, and Haruhiko Akiyama. Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25. Nature Communications 2, Article number: 251. 2011
  2. Kenichiro Furuyama, Yoshiya Kawaguchi, Haruhiko Akiyama, Masashi Horiguchi, Sota Kodama, Takeshi Kuhara, Shinichi Hosokawa, Ashraf Elbahrawy, Tsunemitsu Soeda, Masayuki Koizumi, Toshihiko Masui, Michiya Kawaguchi, Kyoichi Takaori, Ryuichiro Doi, Eiichiro Nishi, Ryosuke Kakinoki, Jian Min Deng, Richard R. Behringer, Takashi Nakamura, and Shinji Uemoto. Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nature Genetics, Jan;43(1):34-41. 2011
  3. Youngwoo Kim, Hiroki Murao, Koji Yamamoto, Jian Min Deng, Richard R. Behringer, Takashi Nakamura, and Haruhiko Akiyama. Generation of transgenic mice for conditional overexpression of Sox9. J Bone Miner Metab. Jan;29(1):123-9. 2011
  4. Tsunemitsu Soeda, Jian Min Deng, Benoit de Crombrugghe, Richard R. Behringer, Takashi Nakamura, and Haruhiko Akiyama. Sox9-expressing Precursors are the Cellular Origin of the Cruciate Ligament of the Knee Joint and the Limb Tendons. Genesis. Nov;48(11):635-44. 2010
  5. Kimura H, Kwan KM, Zhang Z, Deng JM, Darnay BG, Behringer RR, Nakamura T, de Crombrugghe B, Akiyama H. Cthrc1 is a positive regulator of osteoblastic bone formation. PLoS ONE. Sep 9;3(9):e3174. 2008
  6. Jianjian Zhu, Eiichiro Nakamura, Minh-Thanh Nguyen, Xiaozhong Bao, Haruhiko Akiyama, Susan Mackem. Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud. Dev Cell. Apr;14(4):624-32. 2008
  7. Haruhiko Akiyama, H. Scott Stadler, James F. Martin, Takahiro M. Ishii, Philip A. Beachy , Takashi Nakamura , and Benoit de Crombrugghe. Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice. Matrix Biology, 26, 224-233, 2007
  8. Rika Nakanishi, Motoyuki Shimizu, Masayuki Mori, Haruhiko Akiyama, Shuzo Okudaira, Bungo Otsuki, Maiko Hashimoto, Keiichi Higuchi, Masanori Hosokawa, Tadao Tsuboyama, Takashi Nakamura. Secreted Frizzled-Related Protein 4 is a negative regulator of peak bone mineral density in SAMP6 mice. Journal of Bone and Mineral Research, 21(11), 1713-1721, 2006.
  9. Haruhiko Akiyama, Jung-Eun Kim,Kazuhisa Nakashima, Gener Balmes, Naomi Iwai, Jian Min Deng, Zhaoping Zhang, James F. Martin, Richard R. Behringer, Takashi Nakamura, and Benoit de Crombrugghe. Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors. Proc. Nat’l. Acad. Sci.,102(41), 14665-14670, 2005.
  10. Haruhiko Akiyama, Jon P. Lyons, Yuko Mori-Akiyama, Xiaohong Yang, Ren Zhang, Zhaoping Zhang, Jian Min Deng, Makoto M. Taketo, Takashi Nakamura, Richard R. Behringer, Pierre D. McCrea, and Benoit de Crombrugghe. Interactions between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev. 18(9), 1072-1087, 2004
  11. Haruhiko Akiyama, Marie-Christine Chaboissier, Richard R. Behringer, David H. Rowitch, Andreas Schedl, Jonathan A. Epstein, and Benoit de Crombrugghe. Essential Role of Sox9 in the Pathway that Controls Formation of Cardiac Valves and Septa. Proc. Nat’l. Acad. Sci.,101(17), 6502-6507, 2004.
  12. Haruhiko Akiyama, Marie-Christine Chaboissier, Richard R. Behringer, David H. Rowitch, Andreas Schedl, Jonathan A. Epstein, and Benoit de Crombrugghe. Essential Role of Sox9 in the Pathway that Controls Formation of Cardiac Valves and Septa. Proc. Nat’l. Acad. Sci.,101(17), 6502-6507, 2004.
  13. Haruhiko Akiyama, Chaboissier MC, Martin JF, Schedl A, de Crombrugghe B: The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev. 16(21), 2813-28, 2002.
  14. Hiromu Ito, Haruhiko Akiyama, Hiroshi Iguchi, Ken-ichi Iyama, Masahiro Miyamoto, Kunitaka Ohsawa and Takashi Nakamura: Molecular cloning and biological activity of a novel lysyl oxidase-related gene expressed in cartilage. Journal of Biological Chemistry, 276(26), 24023-24029, 2001
  15. Haruhiko Akiyama, Yuji Hiraki , Makoto Noda, Chohei Shigeno, Hiromu Ito, and Takashi Nakamura: Molecular cloning and biological activity of a novel H-Ras suppressor gene predominantly expressed in skeletal muscle, heart, brain and bone marrow by differential display using clonal mouse EC cells, ATDC5. Journal of Biological Chemistry, 274(45), 32192-32197, 1999

人工材料

 

  1. Strontium and magnesium ions released from bioactive titanium metal promote early bone bonding in a rabbit implant model. Okuzu Y, Fujibayashi S, Yamaguchi S, Yamamoto K, Shimizu T, Sono T, Goto K,Otsuki B, Matsushita T, Kokubo T, Matsuda S. Acta Biomater. 2017 Nov;63:383-392.
  2. In vivo experimental study of anterior cervical fusion using bioactive polyetheretherketone in a canine model.Shimizu T, Fujibayashi S, Yamaguchi S,Otsuki B, Okuzu Y, Matsushita T, Kokubo T, Matsuda S.PLoS One. 2017 Sep 8;12(9):
  3. Utility of a custom screw insertion guide and a full-scale, color-coded 3D plaster model for guiding safe surgical exposure and screw insertion during spine revision surgery. Otsuki B, Takemoto M, Fujibayashi S, Kimura H, Masamoto K, Matsuda S. J Neurosurg Spine. 2016 Mar 11:1-9.
  4. Bioactivity of sol-gel-derived TiO2 coating on polyetheretherketone: In vitro and in vivo studies. Shimizu T, Fujibayashi S, Yamaguchi S, Yamamoto K, Otsuki B, Takemoto M, Tsukanaka M, Kizuki T, Matsushita T, Kokubo T, Matsuda S. Acta Biomater. 2016 Feb 6. pii: S1742-7061(16)30049-6. doi: 10.1016/j.actbio.2016.02.007. [Epub ahead of print]
  5. Effect of pore size on bone ingrowth into porous titanium implants fabricated by additive manufacturing: An in vivo experiment. Taniguchi N, Fujibayashi S, Takemoto M, Sasaki K, Otsuki B, Nakamura T, Matsushita T, Kokubo T, Matsuda S. Mater Sci Eng C Mater Biol Appl. 2016 Feb 1;59:690-701. doi: 10.1016/j.msec.2015.10.069. Epub 2015 Oct 28.
  6. Osteoinductive potential of highly purified porous β-TCP in mice. Tsukanaka M, Fujibayashi S, Otsuki B, Takemoto M, Matsuda S. J Mater Sci Mater Med. 2015 Mar;26(3):5469.
  7. Otsuki B, Takemoto M, Kawanabe K, Awa Y, Akiyama H, Fujibayashi S, Nakamura T, Matsuda S. Developing a novel custom cutting guide for curved peri-acetabular osteotomy.Int Orthop. 2013 Jun;37(6):1033-8. doi: 10.1007/s00264-013-1873-x. Epub 2013 Apr 9.
  8. Kawai T, Takemoto M, Fujibayashi S, Akiyama H, Yamaguchi S, Pattanayak DK, Doi K, Matsushita T, Nakamura T, Kokubo T, Matsuda S.,Osteoconduction of porous Ti metal enhanced by acid and heat treatments. J Mater Sci Mater Med. 2013 Jul;24(7):1707-15. doi: 10.1007/s10856-013-4919-0. Epub 2013 Mar 27.
  9. Kawai T, Takemoto M, Fujibayashi S, Neo M, Akiyama H, Yamaguchi S, Pattanayak DK, Matsushita T, Nakamura T, Kokubo T.,Bone-bonding properties of Ti metal subjected to acid and heat treatments. J Mater Sci Mater Med. 2012 Dec;23(12):2981-92. doi: 10.1007/s10856-012-4758-4. Epub 2012 Sep 5.
  10. Fujibayashi S, Takemoto M, Neo M, Matsushita T, Kokubo T, Doi K, Ito T, Shimizu A, Nakamura T. A novel synthetic material for spinal fusion: a prospective clinical trial of porous bioactive titanium metal for lumbar interbody fusion. Eur Spine J. 2011 Sep;20(9):1486-95. doi: 10.1007/s00586-011-1728-3. Epub 2011 Mar 3.
  11. Fukuda A, Takemoto M, Saito T, Fujibayashi S, Neo M, Pattanayak DK, Matsushita T, Sasaki K, Nishida N, Kokubo T, Nakamura T. Osteoinduction of porous Ti implants with a channel structure fabricated by selective laser melting. Acta Biomater. 2011 May;7(5):2327-36. doi: 10.1016/j.actbio.2011.01.037. Epub 2011 Feb 2.
  12. Akiyama N, Takemoto M, Fujibayashi S, Neo M, Hirano M, Nakamura T. Difference between dogs and rats with regard to osteoclast-like cells in calcium-deficient hydroxyapatite-induced osteoinduction. J Biomed Mater Res A. 2011 Feb;96(2):402-12. doi: 10.1002/jbm.a.32995. Epub 2010 Dec 8.
  13. Tanaka K, Takemoto M, Fujibayashi S, Neo M, Shikinami Y, Nakamura T.A bioactive and bioresorbable porous cubic composite scaffold loaded with bone marrow aspirate: a potential alternative to autogenous bone grafting. Spine (Phila Pa 1976). 2011 Mar 15;36(6):441-7. doi: 10.1097/BRS.0b013e3181d39067.
  14. Saito T, Takemoto M, Fukuda A, Kuroda Y, Fujibayashi S, Neo M, Honjoh D, Hiraide T, Kizuki T, Kokubo T, Nakamura T. Effect of titania-based surface modification of polyethylene terephthalate on bone-implant bonding and peri-implant tissue reaction. Acta Biomater. 2011 Apr;7(4):1558-69. doi: 10.1016/j.actbio.2010.11.018. Epub 2010 Nov 24.
  15. Fukuda A, Takemoto M, Saito T, Fujibayashi S, Neo M, Yamaguchi S, Kizuki T, Matsushita T, Niinomi M, Kokubo T, Nakamura T. Bone bonding bioactivity of Ti metal and Ti-Zr-Nb-Ta alloys with Ca ions incorporated on their surfaces by simple chemical and heat treatments. Acta Biomater. 2011 Mar;7(3):1379-86. doi: 10.1016/j.actbio.2010.09.026. Epub 2010 Sep 29.
  16. Pattanayak DK, Fukuda A, Matsushita T, Takemoto M, Fujibayashi S, Sasaki K, Nishida N, Nakamura T, Kokubo T. Bioactive Ti metal analogous to human cancellous bone: Fabrication by selective laser melting and chemical treatments. Acta Biomater. 2011 Mar;7(3):1398-406. doi: 10.1016/j.actbio.2010.09.034. Epub 2010 Sep 29.
  17. Kokubo T, Pattanayak DK, Yamaguchi S, Takadama H, Matsushita T, Kawai T, Takemoto M, Fujibayashi S, Nakamura T.Positively charged bioactive Ti metal prepared by simple chemical and heat treatments. J R Soc Interface. 2010 Oct 6;7 Suppl 5:S503-13. doi: 10.1098/rsif.2010.0129.focus. Epub 2010 May 5.
  18. So K, Takemoto M, Fujibayashi S, Neo M, Kokubo T, Nakamura T. Reinforcement of tendon attachment to bioactive porous titanium by BMP-2-induced ectopic bone formation. J Biomed Mater Res A. 2010 Jun 15;93(4):1410-6. doi: 10.1002/jbm.a.32640.
  19. Nasu T, Takemoto M, Akiyama N, Fujibayashi S, Neo M, Nakamura T. EP4 agonist accelerates osteoinduction and degradation of beta-tricalcium phosphate by stimulating osteoclastogenesis. J Biomed Mater Res A. 2009 Jun;89(3):601-8. doi: 10.1002/jbm.a.31984.
  20. Onishi E, Fujibayashi S, Takemoto M, Neo M, Maruyama T, Kokubo T, Nakamura T. Enhancement of bone-bonding ability of bioactive titanium by prostaglandin E2 receptor selective agonist.Biomaterials. 2008 Mar;29(7):877-83. Epub 2007 Nov 28.
  21. Takemoto M, Fujibayashi S, Neo M, So K, Akiyama N, Matsushita T, Kokubo T, Nakamura T. A porous bioactive titanium implant for spinal interbody fusion: an experimental study using a canine model.J Neurosurg Spine. 2007 Oct;7(4):435-43.
  22. Goto K, Hashimoto M, Takadama H, Tamura J, Fujibayashi S, Kawanabe K, Kokubo T, Nakamura T. Mechanical, setting, and biological properties of bone cements containing micron-sized titania particles. J Mater Sci Mater Med. 2008 Mar;19(3):1009-16. Epub 2007 Aug 1.
  23. So K, Takemoto M, Fujibayashi S, Neo M, Kyomoto M, Hayami T, Hyon SH, Nakamura T. Antidegenerative effects of partial disc replacement in an animal surgery model.Spine (Phila Pa 1976). 2007 Jul 1;32(15):1586-91.
  24. Hasegawa S, Neo M, Tamura J, Fujibayashi S, Takemoto M, Shikinami Y, Okazaki K, Nakamura T. In vivo evaluation of a porous hydroxyapatite/poly-DL-lactide composite for bone tissue engineering.J Biomed Mater Res A. 2007 Jun 15;81(4):930-8.
  25. Liang B, Fujibayashi S, Fujita H, Ise K, Neo M, Nakamura T.Long-term follow-up study of bioactive bone cement in canine total hip arthroplasty. J Long Term Eff Med Implants. 2006;16(4):291-9.
  26. Liang B, Fujibayashi S, Fujita H, Ise K, Neo M, Nakamura T. Long-term follow-up study of bioactive bone cement in canine total hip arthroplasty. J Long Term Eff Med Implants. 2006;16(4):291-9
  27. Shikinami Y, Okazaki K, Saito M, Okuno M, Hasegawa S, Tamura J, Fujibayashi S, Nakamura T. Bioactive and bioresorbable cellular cubic-composite scaffolds for use in bone reconstruction. J R Soc Interface. 2006 Aug 8
  28. Otsuki B, Takemoto M, Fujibayashi S, Neo M, Kokubo T, Nakamura T. Pore throat size and connectivity determine bone and tissue ingrowth into porous implants: Three-dimensional micro-CT based structural analyses of porous bioactive titanium implants. Biomaterials. 2006 Dec;27(35):5892-900. Epub 2006 Sep 1.
  29. B. Liang, S. Fujibayashi, H. Fujita, K. Ise, M. Neo, T. Nakamura, “Long-term follow-up study of bioactive bone cement in canine total hip arthroplasty” J. Long Term Eff. Med. Implants, 16, 291-300, (2006)
  30. Goto K, Shinzato S, Fujibayashi S, Tamura J, Kawanabe K, Hasegawa S, Kowalski R, Nakamura T. The biocompatibility and osteoconductivity of a cement containing beta-TCP for use in vertebroplasty. J Biomed Mater Res A. 2006 Sep 1;78(3):629-37.
  31. So K, Fujibayashi S, Neo M, Anan Y, Ogawa T, Kokubo T, Nakamura T. Accelerated degradation and improved bone-bonding ability of hydroxyapatite ceramics by the addition of glass. Biomaterials. 2006 Sep;27(27):4738-44. Epub 2006 Jun 6.
  32. Takemoto M, Fujibayashi S, Neo M, Suzuki J, Kokubo T, Nakamura T. Bone-bonding ability of a hydroxyapatite coated zirconia-alumina nanocomposite with a microporous surface. J Biomed Mater Res A. 2006 May 31;78A(4):693-701
  33. Takemoto M, Fujibayashi S, Neo M, Suzuki J, Matsushita T, Kokubo T, Nakamura T. Osteoinductive porous titanium implants: Effect of sodium removal by dilute HCl treatment. Biomaterials. 2006 May;27(13):2682-91.
  34. Suzuki T, Fujibayashi S, Nakagawa Y, Noda I, Nakamura T. Ability of zirconia double coated with titanium and hydroxyapatite to bond to bone under load-bearing conditions. Biomaterials. 2006 Oct;27(7):996-1002
  35. Hasegawa S, Ishii S, Tamura J, Furukawa T, Neo M, Matsusue Y, Shikinami Y, Okuno M, Nakamura T. A 5-7 year in vivo study of high-strength hydroxyapatite/poly(L-lactide) composite rods for the internal fixation of bone fractures.Biomaterials. 2006 Mar;27(8):1327-32.
  36. Goto K, Tamura J, Shinzato S, Fujibayashi S, Hashimoto M, Kawashita M, Kokubo T, Nakamura T. Bioactive bone cements containing nano-sized titania particles for use as bone substitutes. Biomaterials. 2005 Nov;26(33):6496-505
  37. Takemoto M, Fujibayashi S, Neo M, Suzuki J, Kokubo T, Nakamura T. Mechanical properties and osteoconductivity of porous bioactive titanium. Biomaterials. 2005 Oct;26(30):6014-23
  38. Goto M,Hashimoto M, Fujibayashi S, Kokubo T, Nakamura T. New Bioactive Bone Cement Containing Nano-Sized Titania Particles. Key Engineering Materials Vols. 284-286: 97-100 2005
  39. Hasegawa S, Tamura J, Neo M, Goto K, Shikinami Y, Saito M, Kita M, Nakamura T. In vivo evaluation of a porous hydroxyapatite/poly-DL-lactide composite for use as a bone substitute. J Biomed Mater Res A. 2005 Dec 1;75(3):567-79.
  40. Fujibayashi S, Neo M, Kim HM, Kokubo T, Nakamura T. Osteoinduction of porous bioactive titanium. Biomaterials 25: 443-450 2004
  41. Ohsawa K, Neo M, Okamoto T, Tamura J, Nakamura T. In vivo absorption of porous apatite- and wollastonite-containing glass-ceramic. J Mater Sci Mater Med. 2004 Aug;15(8):859-64.
  42. Shinzato S, Nakamura T, Kawanabe K, Kokubo T. In vivo aging test for a bioactive bone cement consisting of glass bead filler and PMMA matrix. J Biomed Mater Res B Appl Biomater. 2004 Feb 15;68(2):132-9.
  43. Fujibayashi S, Kim HM, Neo M, Uchida M. Kokubo T, Nakamura T. Repair of segmental long bone defect in rabbit femur using bioactive titanium cylindrical mesh cage. Biomaterials 24: 3445-3451 2003
  44. Liang B, Fujibayashi S, Tamura J, Neo M, Kim HM, Uchida M, Kokubo T, Nakamura T. Histological and mechanical investigation of the bone-bonding ability of anodically oxidized titanium in rabbits. Biomaterials. 2003 Dec; 24(27):4959-66.
  45. Nishiguchi S, Fujibayashi S, Kim HM, Kokubo T, Nakamura T. Biology of alkali- and heat-treated titanium implants. J Biomed Mater Res A. 2003 Oct 1;67(1):26-35.
  46. Fujibayashi S, Neo M, Kim HM, Kokubo T, Nakamura T. A comparative study between in vivo bone ingrowth and in vitro apatite formation on Na(2)O-CaO-SiO(2) glasses. Biomaterials. 24(8): 1349-56 2003
  47. Uchida M, Kim HM, Kokubo T, Fujibayashi S, Nakamura T. Structural dependence of apatite formation on titania gels in a simulated body fluid. J Biomed Mater Res. 64(1): 164-70 2003
  48. Ishii S, Tamura J, Furukawa T, Nakamura T, Matsusue Y, Shikinami Y, Okuno M. Long-term study of high-strength hydroxyapatite/poly(L-lactide) composite rods for the internal fixation of bone fractures: a 2-4-year follow-up study in rabbits. J Biomed Mater Res B Appl Biomater. 2003 Aug 15;66(2):539-47.
  49. Tanaka K, Tamura J, Kawanabe K, Nawa M, Uchida M, Kokubo T, Nakamura T. Phase stability after aging and its influence on pin-on-disk wear properties of Ce-TZP/Al2O3 nanocomposite and conventional Y-TZP. J Biomed Mater Res A. 2003 Oct 1;67(1):200-7.
  50. Tanaka K, Tamura J, Kawanabe K, Shimizu M, Nakamura T. Effect of alumina femoral heads on polyethylene wear in cemented total hip arthroplasty. Old versus current alumina. J Bone Joint Surg Br. 2003 Jul;85(5):655-60.
  51. Shinzato S, Nakamura T, Kawanabe K, Kokubo T. PMMA-based bioactive cement: effect of CaF2 on osteoconductivity and histological change with time. J Biomed Mater Res B Appl Biomater. 2003 May 15;65(2):262-71.
  52. Tanaka K, Tamura J, Kawanabe K, Nawa M, Oka M, Uchida M, Kokubo T, Nakamura T. Ce-TZP/Al2O3 nanocomposite as a bearing material in total joint replacement. J Biomed Mater Res. 2002;63(3):262-70.
  53. Kamimura M, Tamura J, Shinzato S, Kawanabe K, Neo M, Kokubo T, Nakamura T. Interfacial tensile strength between polymethylmethacrylate-based bioactive bone cements and bone.　J Biomed Mater Res. 2002 Sep 15;61(4):564-71.
  54. Shinzato S, Nakamura T, Kokubo T, Kitamura Y. Composites consisting of poly(methyl methacrylate) and alumina powder: an evaluation of their mechanical and biological properties.　J Biomed Mater Res. 2002 Jun 15;60(4):585-91.
  55. Shinzato S, Nakamura T, Ando K, Kokubo T, Kitamura Y. Mechanical properties and osteoconductivity of new bioactive composites consisting of partially crystallized glass beads and poly(methyl methacrylate). J Biomed Mater Res. 2002 Jun 15;60(4):556-63.
  56. Shinzato S, Nakamura T, Kokubo T, Kitamura Y. PMMA-based bioactive cement: effect of glass bead filler content and histological change with time.J Biomed Mater Res. 2002 Feb;59(2):225-32.
  57. Fujibayashi S, Senaha Y, Yoshihara S, Tamura J, Nakamura T. Long-term follow-up study of bioactive bone cement for repairing a segmental defect in a canine femur. J Long Term Eff Med Implants. 11(1-2): 93-103 2001
  58. Fujibayashi S, Nakamura T, Nishiguchi S, Tamura J, Uchida M, Kim HM, Kokubo T. Bioactive titanium: effect of sodium removal on the bone-bonding ability of bioactive titanium prepared by alkali and heat treatment. J Biomed Mater Res. 56(4):562-70 2001
  59. Ohsawa K, Neo M, Matsuoka H, Akiyama H, Ito H, Nakamura T. Tissue responses around polymethylmethacrylate particles implanted into bone: analysis of expression of bone matrix protein mRNAs by in situ hybridization. J Biomed Mater Res. 2001 Mar 15;54(4):501-8.
  60. Shinzato S, Nakamura T, Kokubo T, Kitamura Y. A new bioactive bone cement: effect of glass bead filler content on mechanical and biological properties. J Biomed Mater Res. 2001 Mar 15;54(4):491-500.
  61. Shinzato S, Nakamura T, Tamura J, Kokubo T, Kitamura Y. Bioactive bone cement: effects of phosphoric ester monomer on mechanical properties and osteoconductivity. J Biomed Mater Res. 2001 Sep 15;56(4):571-7.
  62. Shinzato S, Nakamura T, Kokubo T, Kitamura Y. Bioactive bone cement: effect of filler size on mechanical properties and osteoconductivity. J Biomed Mater Res. 2001 Sep 5;56(3):452-8.
  63. Shinzato S, Nakamura T, Kokubo T, Kitamura Y. Bioactive bone cement: Effect of silane treatment on mechanical properties and osteoconductivity. J Biomed Mater Res. 2001 Jun 5;55(3):277-84.
  64. Nishiguchi S, Kato H, Fujita H, Oka M, Kim HM, Kokubo T, Nakamura T. Titanium metals form direct bonding to bone after alkali and heat treatments. Biomaterials. 2001 Sep;22(18):2525-33.
  65. Nishiguchi S, Kato H, Neo M, Oka M, Kim HM, Kokubo T, Nakamura T. Alkali- and heat-treated porous titanium for orthopedic implants.J Biomed Mater Res. 2001 Feb;54(2):198-208.
  66. リウマチ・骨軟骨再生

関節リウマチにおける酸化脂質の役割

  1. Masahiro Ishikawa, Hiromu Ito, Miki Akiyoshi, Noriaki Kume, Hiroyuki Yoshitomi, Hirokazu Mitsuoka, Shimei Tanida, Koichi Murata, Hideyuki Shibuya, Takashi Kasahara, Akemi Kakino, Yoshiko Fujita, Tatsuya Sawamura, Tadashi Yasuda, Takashi Nakamura: Lectin-like oxidized LDL receptor-1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis. Arthritis and Rheumatism 64:1024-1034, 2012
  2. Kakinuma T, Yasuda T, Nakagawa T,et al. Lectin-like oxidized low-density lipoprotein receptor 1 mediates matrix metalloproteinase 3 synthesis enhanced by oxidized low-density lipoprotein in rheumatoid arthritis cartilage. Arthritis Rheum 50:3495-503、2004
  3. Nakagawa T, Yasuda T, Hoshikawa H, et al. LOX-1 expressed in cultured rat chondrocytes mediates oxidized LDL-induced cell death-possible role of dephosphorylation of Akt. Biochem Biophys Res Com 299:91-7, 2002.
  4. Nakagawa T, Akagi M, Hoshikawa H, et al. Lectin-like Oxidized low-density lipoprotein receptor-1 mediates leukocyte infiltration and articular cartilage destruction in rat zymosan induced arthritis. Arthritis Rheum 46:2486-94, 2002.

関節リウマチ特異的な関節液・血漿中マイクロRNAの研究

  1. 1. Koichi Murata, Moritoshi Furu, Hiroyuki Yoshitomi, Masahiro Ishikawa, Hideyuki Shibuya, Motomu Hashimoto, Yoshitaka Imura, Takao Fujii, Hiromu Ito, Tsuneyo Mimori, Shuichi Matsuda: Comprehensive microRNA analysis identifies miR-24, miR-26a, and miR-125a-5p as plasma biomarkers for rheumatoid arthritis. PLoS ONE 2013 (in press)
  2. Murata K, Yoshitomi H, Tanida S, et al. Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis. Arthritis Res Ther. 12(3):R86, 2010

関節リウマチ特異的なTリンパ球の研究

  1. Shimei Tanida, Hiroyuki Yoshitomi, Kohei Nishitani, Masahiro Ishikawa, Takashi Kasahara, Koichi Murata, Hideyuki Shibuya, Hiromu Ito, Takashi Nakamura: IL-27-producing-CD14+cells infiltrate in inflamed joint of rheumatoid arthritic and regulate inflammation and chemotactic migration Cytokine 55:237-244
  2. Hashimoto M, Hirota K, Yoshitomi H, et al. Complement drives Th17 cell differentiation and triggers autoimmune arthritis. J Exp Med. 207(6):1135-43, 2010
  3. Tanida S, Yoshitomi H, Nishitani K, et al. CCL20 produced in the cytokine network of rheumatoid arthritis recruits CCR6+ mononuclear cells and enhances the production of IL-6. Cytokine. 2009 47(2):112-8, 2009
  4. Hirota K, Yoshitomi H, Hashimoto M, et al. Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J Exp Med. 204(12):2803-12, 2007
  5. Hirota K, Hashimoto M, Yoshitomi H, et al. T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J Exp Med 204(1):41-7, 2007
  6. Yoshitomi H, Sakaguchi N, Kobayashi K, et al. A role for fungal beta-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice. J Exp Med 201:949-60, 2005
  7. Hata H, Sakaguchi N, Yoshitomi H, et al. Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice. J Clin Invest 114:582-8, 2004

骨軟骨再生

  1. Koichi Murata, Hiromu Ito, Hiroyuki Yoshitomi, Koji Yamamoto, Akinobu Fukuda, Junsuke Yoshikawa, Moritoshi Furu, Masahiro Ishikawa, Hideyuki Shibuya, Shuichi Matsuda: Inhibition of miR-92a Enhances Fracture Healing via Promoting Angiogenesis in a Model of Stabilized Fracture in Young Mice. J Bone Miner Res 2013 (in press)
  2. Hiromu Ito: Chemokines in Mesenchymal Stem Cell Therapy for Bone Repair – A novel concept of recruiting mesenchymal stem cells and the possible cell sources – Mod Rheumatol 2011 (in press)
  3. Tomonori Nasu, Hiromu Ito, Ryosuke Tsutsumi, et al. Biological Activation of Bone-related Biomaterials by Recombinant Adeno-associated Virus Vector. J Orthop Res 27:1162-1168, 2009
  4. Toshiyuki Kitaori, Hiromu Ito, Edward M. Schwarz, et al. SDF-1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair. Arthritis Rheum 60:813-823, 2009
  5. Zhang X, Xie C, Lin AS, Ito H, et al. Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering. J Bone Miner Res 20:2124-2137, 2005
  6. Ito H, Koefoed M, Tiyapatanaputi P, et al. Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy. Nature Med 11:291-7, 2005

ヒアルロン酸研究

  1. Sohel M. Julovi, Hiromu Ito, Kohei Nishitani, et al. Hyaluronan Inhibits Matrix metalloproteinase-13 in Human Arthritic Chondrocytes via CD44 and P38. Journal of Orthopaedic Research 29:258-264, 2011
  2. Sohel M. Julovi, Hiromu Ito, Teruko Hiramitsu, et al. Hyaluronan Inhibits IL-1β-Stimulated Collagenase Production via Down-regulation of Phosphorylated p38 in SW-1353 human chondrosarcoma cells. Mod Rheumatol18:263-270, 2008
  3. Hiramitsu T, Yasuda T, Ito H, et al. Intercellular adhesion molecule-1 mediates the inhibitory effects of hyaluronan on interleukin-1b-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts via down-regulation of NF-kB and p38. Rheumatology (Oxford). 45(7):824-32,2006
  4. Julovi SM, Yasuda T, Shimizu M, et al. Inhibition of interleukin-1beta-stimulated production of matrix metalloproteinases by hyaluronan via CD44 in human articular cartilage. Arthritis Rheum 50:516-25, 2004

軟骨細胞分化、関節軟骨変性の基礎的研究

  1. Koichi Murata, Toshiyuki Kitaori, Shinya Oishi, Naoki Watanabe, Hiroyuki Yoshitomi, Shimei Tanida, Masahiro Ishikawa, Takashi Kasahara, Hideyuki Shibuya, Nobutaka Fujii, Takashi Nagasawa, Takashi Nakamura, Hiromu Ito: Stromal cell-derived factor 1 regulates the actin organization of chondrocytes and chondrocyte hypertrophy. PLoS ONE 7(5): e37163, 2012
  2. K. Nishitani, H. Ito, T. Hiramitsu, R. et al. PGE2 inhibits MMP expression by suppressing MKK4-JNK MAP kinase-c-JUN pathway via EP4 in human articular chondrocytes. J Cell Biochem 109:425-433, 2010
  3. R. Tsutsumi, H. Ito, T. Hiramitsu, et al. Celecoxib inhibits production of MMP and NO via down-regulation of NF-κB and JNK in a PGE2 independent manner in human articular chondrocytes. Rheumatol Int 28:727-736, 2008
  4. Mukai S, Ito H, Nakagawa Y, et al.　Transforming growth factor-beta-1 mediates the effects of low-intensity pulsed ultrasound in chondrocytes. Ultrasound Med Biol 31:1713-21, 2005
  5. M. Miyamoto, H. Ito, S. Mukai, et al. Simultaneous stimulation of EP2 and EP4 is essential to the effect of prostaglandin E2 in chondrocyte differentiation. Osteoarthritis Cartilage 11:644-52, 2003
  6. Ito H, Akiyama H, Iguchi H, et al. Molecular cloning and biological activity of a novel lysyl oxidase-related gene expressed in cartilage. J Biol Chem 276:24023-9, 2001

 

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